Population
genetics deals with terms like gene pools, allelic
frequencies,
genotypic frequencies, phenotypic frequencies. Instead of
studying the
gene from the level of the molecule, cell, or organism, it
looks a gene
from the population point of view. A population is a local
group of
organisms of the same species (interbreeding or
potentially so). |
Hardy-Weinberg Equilibrium: This
mathematical
expression predicts what proportions to expect in each of
the three genotypic classes (looking at only one gene and
assuming
there are only two alleles).
- Genotypic Frequencies
Are Determined by Allelic Frequencies (Gene
Frequencies): The frequency of AA
individuals should be p2, Aa
2pq, and aa q2. (p is the
allelic frequency of A in the gene pool and q
is the allelic frequency of a in the gene pool). If we
assume HW
equilibrium, we can estimate the gene and genotypic
frequencies from
the homozygous recessive frequency (q2=[aa]).
HW equilibrium applies to autosomal genes and to X
linked genes in females.
- Assumptions
of Hardy-Weinberg Equilibrium: These
frequencies will be observed if we assume the
following.
- Large, Randomly
Mating Population
- No Selection
- No Mutation
- No Migration (no
immigration or emigration)
Changes in Gene Frequency: The
gene and genotypic frequencies will not remain at HW
equilibrium if the above condition are not met.
- Selection: With
selection,
all genotypes are not equally viable. Fitness values
(W) and
selection coefficients (s) are assigned to different
genotypes
- Complete Selection:
With complete selection against aa,
it is assigned an s value of 1.
- qnew=qold/(1+qold)
- qn=q0/(1+nq0)
- Partial Selection: With
partial selection against aa, it is assigned an s
value less than 1 but greater than 0.
- qnew=(qold(1-sqold))/(1+sqold)
- Heterozygote
Advantage: With
this type of selection, both homozygotes are
selected against (have an
s value greater than 0). Sickle-cell anemia in a
malaria environment is
an example of this kind of selection. The value of q
will reach an
equilibrium independent of the initial genotypic
frequencies.
- q at equilibrium = s1/(s1+s3)
- Drift: If
the
mating population is small, dramatic fluctuations in
gene and
genotypic frequencies may be seen due to sampling
error. Founder's
Principle is a "one-time" drift event due to a new
population being
founded from a small sample of the original
population.
- Inbreeding: Inbreeding
does not change the gene frequency but changes the
genotypic frequencies.
- Migration
Balanced
Polymorphisms: In
nature, population often exist with genotypic frequencies
balanced at
some level. This may be due to neutral mutations,
heterozygous
advantage, equilibrium between mutation and selection,
equilibrium
between forward and backward mutation, or
density-dependent selection.
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